Research
Mixed
In patients with new-onset type 2 diabetes, weight change (gain or loss) of more than 10% is associated with higher all-cause mortality compared to stable weight.
If you have recently been diagnosed with type 2 diabetes, aim to maintain your weight. Both losing more than 10% and gaining more than 10% of your body weight in the first two years are associated with higher mortality. Stable weight is linked to the lowest risk of death.
GoodQualifiesHIGH confidence
All-cause mortality showed a U-shaped curve according to weight change. The group with weight loss ≥ − 10% had the highest HR for all-cause mortality (HR, 1.86; 95% CI 1.61–2.14) and the HR for the group with weight gain ≥ + 10% was 1.61 (95% CI 1.37–1.89).
Why this rating
Large cohort, robust statistical adjustment, but observational design limits causal inference.
Source
Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
Mee Kyoung Kim et al. · Cardiovascular Diabetology · 2019
cohort · n=173246Cited 62×
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