Research
Cellular
A reduction in muscle protein synthesis (MPS) is the main mechanism that underpins lean body mass (LBM) loss early in energy restriction (ER) in adult men.
Practitioners should focus on maintaining MPS to preserve LBM during energy restriction.
StrongSupportsmedium confidence
We conclude that a reduction in MPS is the main mechanism that underpins LBM loss early in ER in adult men.
Why this rating
Based on study design from abstract.
Source
Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise
Amy J. Hector et al. · The FASEB Journal · 2017
DOI 10.1096/fj.201700158rr
rct · n=24Cited 86×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Cellular
- Athletes aiming to reduce fat mass and preserve FFM should consume protein intakes in the range of ∼1.8-2.7 g kg(-1) d(-1).Strong
- A minimum daily protein intake of ≥1.6 g/kg is necessary to observe significant improvements in muscle mass from whey protein supplementation.Strong
- Most athletes ideally need 1.2 to 2.0 grams/kg of body weight/day of protein, preferably split across 3-4 meals.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →