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Cellular
EPA, DPA, DHA, and their sum were associated with lower T2D incidence with hazard ratios of 0.92, 0.79, 0.82, and 0.81 respectively.
The specific hazard ratios suggest that increasing levels of these fatty acids may significantly reduce T2D risk.
StrongSupportsmedium confidence
In pooled multivariable analysis, per interquintile range, EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively.
Why this rating
Based on a pooled analysis of 20 prospective cohort studies.
Source
n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
Frank Qian et al. · Diabetes Care · 2021
DOI 10.2337/dc20-2426
Meta-analysisCited 78×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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