Research
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Discontinuing GLP-1RA treatment leads to a pooled overall mean weight regain of 2.20 kg in participants taking liraglutide and 9.69 kg in those prescribed semaglutide/tirzepatide.
Practitioners should consider the likelihood of weight regain when discontinuing GLP-1RA therapy.
StrongSupportsmedium confidence
discontinuing GLP‐1RA treatment led to a pooled overall mean weight regain of 2.20 kg in participants taking liraglutide and 9.69 kg in those patients prescribed semaglutide/tirzepatide.
Why this rating
Based on the systematic review and meta-analysis of randomized controlled trials.
Source
Discontinuing glucagon‐like peptide‐1 receptor agonists and body habitus: A systematic review and meta‐analysis
Sara Berg et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13929
Meta-analysisCited 71×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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