Research
Energy balance
Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions.
Clinicians should inform patients that stopping GLP-1RA may lead to weight regain despite lifestyle efforts.
StrongSupportsmedium confidence
Discontinuation of GLP‐1RA treatment leads to weight regain, regardless of lifestyle interventions.
Why this rating
Based on the systematic review and meta-analysis of randomized controlled trials.
Source
Discontinuing glucagon‐like peptide‐1 receptor agonists and body habitus: A systematic review and meta‐analysis
Sara Berg et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13929
Meta-analysisCited 71×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Discontinuing GLP-1RA treatment leads to a pooled overall mean weight regain of 2.20 kg in participants taking liraglutide and 9.69 kg in those prescribed semaglutide/tirzepatide.Strong
- The proportion of weight regained after discontinuation of GLP-1RA therapy is proportional to the amount originally lost.Strong
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