Research
Energy balance
The proportion of weight regained after discontinuation of GLP-1RA therapy is proportional to the amount originally lost.
Weight loss strategies should account for the likelihood of proportional weight regain after stopping GLP-1RA therapy.
StrongSupportsmedium confidence
The proportion of weight regained was proportional to the amount originally lost.
Why this rating
Based on the systematic review and meta-analysis of randomized controlled trials.
Source
Discontinuing glucagon‐like peptide‐1 receptor agonists and body habitus: A systematic review and meta‐analysis
Sara Berg et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13929
Meta-analysisCited 71×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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