Research
Metabolic adaptation
Leptin replacement prevented the decrease in energy expenditure after weight loss in congenital leptin-deficient subjects.
Leptin replacement therapy may be beneficial for maintaining energy expenditure in patients with congenital leptin deficiency after weight loss.
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In congenital leptin-deficient subjects, leptin replacement prevented the decrease in energy expenditure and fat oxidation often observed after weight loss.
Why this rating
Based on study design from abstract.
Source
Leptin Replacement Prevents Weight Loss-Induced Metabolic Adaptation in Congenital Leptin-Deficient Patients
José E. Galgani et al. · The Journal of Clinical Endocrinology & Metabolism · 2010
cohort · n=6Cited 59×
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