Research
Energy balance
Leptin-treated subjects had energy expenditures not different from the reference population after weight loss.
Leptin therapy may help maintain energy expenditure levels similar to those of healthy individuals post-weight loss.
StrongSupportsmedium confidence
Leptin-treated subjects had values not different from the reference population (-128 +/- 119 kcal/d; P = 0.67).
Why this rating
Based on study design from abstract.
Source
Leptin Replacement Prevents Weight Loss-Induced Metabolic Adaptation in Congenital Leptin-Deficient Patients
José E. Galgani et al. · The Journal of Clinical Endocrinology & Metabolism · 2010
DOI 10.1210/jc.2009-1739
cohort · n=6Cited 59×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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