Research
Metabolic adaptation
The obesity paradox was not observed among those with coronary heart disease (CHD), with an adjusted hazard ratio of 1.00 (95% CI 0.86, 1.17).
Clinicians should be cautious in applying the obesity paradox to patients with coronary heart disease.
StrongRefutesmedium confidence
The obesity paradox was observed among people with type 2 diabetes... but not among those with CHD (1.00 [0.86, 1.17]).
Why this rating
Based on the large cohort study design from the abstract.
Source
Adiposity-Mortality Relationships in Type 2 Diabetes, Coronary Heart Disease, and Cancer Subgroups in the UK Biobank, and Their Modification by Smoking
David Jenkins et al. · Diabetes Care · 2018
cohort · n=45790Cited 55×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →