Research
Molecular
Higher plasma concentrations of TMAO are associated with a 30% increased risk of death from any cause among older adults.
Practitioners should consider monitoring TMAO levels in older adults as a potential risk factor for mortality.
StrongSupportsmedium confidence
After adjustment for potential confounders, the hazard ratios for death from any cause (ie, total mortality) comparing extreme quintiles (fifth vs first) of plasma concentrations were 1.30 (95% CI, 1.17-1.44) for TMAO.
Why this rating
Based on a large prospective cohort study design.
Source
Association of Trimethylamine <i>N</i>-Oxide and Metabolites With Mortality in Older Adults
Amanda M. Fretts et al. · JAMA Network Open · 2022
cohort · n=5333Cited 51×
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