Research
Molecular
The hazard ratio of type 2 diabetes per increment of 10 risk alleles in the polygenic risk score is 1.64 (95% CI 1.54 to 1.75).
Genetic predisposition significantly increases the risk of developing type 2 diabetes.
StrongSupportsmedium confidence
The hazard ratio of type 2 diabetes per increment of 10 risk alleles in the polygenic risk score was 1.64 (95% confidence interval 1.54 to 1.75, I 2 =7.1%, τ 2 =0.003).
Why this rating
Based on a meta-analysis of individual participant data.
Source
Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis
Jordi Merino et al. · BMJ · 2019
DOI 10.1136/bmj.l4292
Meta-analysisCited 48×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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