Research

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Semaglutide showed a favorable hepatic safety profile with no discontinuations due to liver enzyme elevations.

Semaglutide can be considered safe for liver health in the studied population.

StrongSupportsmedium confidence
Semaglutide showed a favorable hepatic safety profile in the ESSENCE trial, with no discontinuations due to liver enzyme elevations.
Meena B. Bansal et al. · Hepatology · 2025

Why this rating

Based on data from a phase 3 trial.

Source

Semaglutide therapy for metabolic dysfunction–associated steatohepatitis: November 2025 updates to AASLD Practice Guidance

Meena B. Bansal et al. · Hepatology · 2025

DOI 10.1097/hep.0000000000001608

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DOI resolved against Crossref · corpus check 2026-06-10

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