Research
Molecular
Calorie restriction (CR) resulted in 88 differentially regulated genes compared to 39 in calorie restriction with exercise (CREX).
Practitioners should note that calorie restriction alone may have a more significant impact on gene regulation than combining it with exercise.
StrongSupportsmedium confidence
CR vastly outweighed CREX in the number of differentially regulated genes (88 vs 39).
Why this rating
The study involved a randomized controlled trial with clear comparisons.
Source
Six-month Calorie Restriction in Overweight Individuals Elicits Transcriptomic Response in Subcutaneous Adipose Tissue That is Distinct From Effects of Energy Deficit
Yan Y. Lam et al. · The Journals of Gerontology Series A · 2015
DOI 10.1093/gerona/glv194
rct · n=24Cited 22×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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