Research
Energy balance
Calorie restriction and CREX elicited similar overall clinical responses to energy deficit.
Both calorie restriction and exercise combined with calorie restriction can lead to similar health outcomes, which may inform dietary and exercise recommendations.
StrongSupportsmedium confidence
CR and CREX elicited similar overall clinical response to energy deficit.
Why this rating
The study design allows for direct comparison of clinical responses.
Source
Six-month Calorie Restriction in Overweight Individuals Elicits Transcriptomic Response in Subcutaneous Adipose Tissue That is Distinct From Effects of Energy Deficit
Yan Y. Lam et al. · The Journals of Gerontology Series A · 2015
DOI 10.1093/gerona/glv194
rct · n=24Cited 22×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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