Research
Molecular
Calorie restriction specifically downregulated chemokine signaling-related pathways.
Understanding the downregulation of chemokine pathways may help in developing targeted interventions for health benefits of calorie restriction.
StrongSupportsmedium confidence
CR specifically downregulated the chemokine signaling-related pathways.
Why this rating
The study design supports the identification of specific pathway changes.
Source
Six-month Calorie Restriction in Overweight Individuals Elicits Transcriptomic Response in Subcutaneous Adipose Tissue That is Distinct From Effects of Energy Deficit
Yan Y. Lam et al. · The Journals of Gerontology Series A · 2015
DOI 10.1093/gerona/glv194
rct · n=24Cited 22×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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