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Treatment with semaglutide was associated with a significant odds of NAION (OR, 3.92; 95% CI, 1.02-15.02).
Clinicians should monitor for NAION in patients treated with semaglutide.
StrongQualifiesmedium confidence
Treatment with semaglutide was associated with a significant odds of NAION (OR, 3.92; 95% CI, 1.02-15.02).
Why this rating
Based on a comprehensive analysis of 78 trials.
Source
Ocular Adverse Events With Semaglutide
Gabriella Richter da Natividade et al. · JAMA Ophthalmology · 2025
DOI 10.1001/jamaophthalmol.2025.2489
Meta-analysisCited 22×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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