Research
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Current evidence remains insufficient to establish definitive conclusions regarding the association of semaglutide with NAION.
Further research is needed to clarify the risk of NAION with semaglutide.
StrongQualifiesmedium confidence
Despite the fact that an association between semaglutide treatment and NAION was found, current evidence remains insufficient to establish definitive conclusions regarding its association with NAION.
Why this rating
Based on a comprehensive analysis of 78 trials.
Source
Ocular Adverse Events With Semaglutide
Gabriella Richter da Natividade et al. · JAMA Ophthalmology · 2025
DOI 10.1001/jamaophthalmol.2025.2489
Meta-analysisCited 22×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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