Research
Neural
GLP-1RA users had a lower risk of dementia (HR, 0.63; 95% CI, 0.50-0.81) compared to other antidiabetic drug users.
Practitioners may consider GLP-1RAs as a treatment option for reducing dementia risk in this population.
StrongSupportsmedium confidence
During a 7-year follow-up, GLP-1RA users had a lower risk of dementia (HR, 0.63; 95% CI, 0.50-0.81).
Why this rating
Based on the large cohort study design.
Source
Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Patients With Diabetes and Obesity
Huan-Tang Lin et al. · JAMA Network Open · 2025
cohort · n=60860Cited 21×
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