Research
Cellular
GLP-1RA users had a lower risk of all-cause mortality (HR, 0.70; 95% CI, 0.63-0.78) compared to other antidiabetic drug users.
Practitioners may consider GLP-1RAs as a treatment option for reducing all-cause mortality in this population.
StrongSupportsmedium confidence
GLP-1RA users had a lower risk of all-cause mortality (HR, 0.70; 95% CI, 0.63-0.78).
Why this rating
Based on the large cohort study design.
Source
Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Patients With Diabetes and Obesity
Huan-Tang Lin et al. · JAMA Network Open · 2025
DOI 10.1001/jamanetworkopen.2025.21016
cohort · n=60860Cited 21×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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