Research
Molecular
DEPTOR is identified as a critical mechanistic candidate for disuse-driven MPS suppression.
Targeting DEPTOR may offer a therapeutic approach to counteract muscle loss during periods of disuse.
StrongSupportsmedium confidence
Notably, we implicate a putative role for muscle protein breakdown‐related molecular networks in impairing MPS during short‐term disuse, and further establish DEPTOR (a potent mTOR inhibitor) as a critical mechanistic candidate of disuse driven MPS suppression in humans.
Why this rating
Based on the identification of DEPTOR's role through experimental analysis.
Source
Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short‐term disuse in healthy younger humans
Craig R. G. Willis et al. · The FASEB Journal · 2021
other · n=8Cited 14×
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