Research
Cellular
Muscle disuse leads to a rapid decline in muscle mass and reduced muscle protein synthesis (MPS).
Practitioners should be aware that muscle disuse can quickly lead to muscle loss and decreased protein synthesis.
StrongSupportsmedium confidence
Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism.
Why this rating
Based on the study design involving RNA sequencing and muscle biopsies.
Source
Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short‐term disuse in healthy younger humans
Craig R. G. Willis et al. · The FASEB Journal · 2021
DOI 10.1096/fj.202100276rr
other · n=8Cited 14×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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