Research
Metabolic adaptation
Tirzepatide-associated improvements in cardiometabolic risk factors are positively related to the degree of weight reduction.
Weight reduction through tirzepatide can lead to significant improvements in cardiometabolic health.
StrongSupportsmedium confidence
In SURMOUNT-1, tirzepatide-associated improvements in cardiometabolic risk factors positively related to the degree of weight reduction.
Why this rating
Based on the phase 3 randomized trial design.
Source
Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide
Bruno Linetzky et al. · Annals of Internal Medicine · 2025
rct · n=1605Cited 9×
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