Research
Metabolic adaptation
Improvements in triglycerides, HDL cholesterol, LDL cholesterol, and non-HDL cholesterol were primarily observed after weight reductions greater than 10%.
Targeting a weight reduction of over 10% may be necessary for significant improvements in lipid profiles.
StrongSupportsmedium confidence
Improvements in levels of triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, and non-HDL cholesterol were primarily observed only after weight reductions greater than 10%.
Why this rating
Based on the phase 3 randomized trial design.
Source
Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide
Bruno Linetzky et al. · Annals of Internal Medicine · 2025
rct · n=1605Cited 9×
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