Research
Metabolic adaptation
The steepest improvements in cardiometabolic risk factors occurred between less than 5% and less than 20% weight reduction.
Practitioners should note that even modest weight loss can lead to significant health improvements, particularly within the 5-20% range.
StrongSupportsmedium confidence
The steepest effect occurring between less than 5% and less than 20% weight reduction.
Why this rating
Based on the phase 3 randomized trial design.
Source
Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide
Bruno Linetzky et al. · Annals of Internal Medicine · 2025
rct · n=1605Cited 9×
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