Research
Neural
Targeted deletion of the receptor in central amygdalar neurons diminishes the anorectic efficacy of GLP1RAs for reward-driven intake.
This finding highlights the importance of specific neural receptors in the effectiveness of weight loss drugs.
StrongSupportsmedium confidence
Targeted deletion of the receptor in this cell population specifically diminishes the anorectic efficacy of GLP1RAs for reward-driven intake.
Why this rating
The study provides clear evidence regarding receptor involvement.
Source
A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Elizabeth Godschall et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2024
otherCited 8×
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