Research
Metabolic adaptation
A sustained weight loss of 3–5% is likely to result in clinically meaningful reductions in triglycerides, blood glucose, and A1C.
Practitioners should aim for a 3-5% weight loss in patients to improve metabolic health.
StrongSupportsmedium confidence
Recently published guidelines on obesity management indicate that a sustained weight loss of 3–5% is likely to result in clinically meaningful reductions in triglycerides, blood glucose, and A1C.
Why this rating
Based on guidelines and evidence from the Look AHEAD trial.
Source
Weight-Loss Intervention by Telephone: Lessons Learned
Judith Wylie‐Rosett · Diabetes Care · 2014
DOI 10.2337/dc14-0628
otherCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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