Research
Metabolic adaptation
Achieving more weight loss (∼10%) will reduce blood pressure, improve LDL cholesterol and HDL cholesterol, and reduce the need for medications required to control cardiometabolic risk.
Practitioners should encourage patients to aim for a 10% weight loss for enhanced cardiometabolic health.
StrongSupportsmedium confidence
However, the 2013 Obesity Guidelines noted achieving more weight loss (∼10%) will also reduce blood pressure, improve LDL cholesterol and HDL cholesterol, and reduce the need for medications required to control cardiometabolic risk.
Why this rating
Based on guidelines and evidence from the Look AHEAD trial.
Source
Weight-Loss Intervention by Telephone: Lessons Learned
Judith Wylie‐Rosett · Diabetes Care · 2014
DOI 10.2337/dc14-0628
otherCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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