Research
Metabolic adaptation
An intensive lifestyle intervention can achieve a 5–10% weight loss and improve sleep apnea quality-of-life indices, achieve cardiometabolic biomarker improvements, and reduce need for medications.
Practitioners should consider intensive lifestyle interventions for diabetic patients to achieve significant health benefits.
StrongSupportsmedium confidence
The Look AHEAD (Actions for Health in Diabetes) trial provides evidence, specific to diabetes, that an intensive lifestyle intervention can achieve a 5–10% weight loss and can improve sleep apnea quality-of-life indices, achieve cardiometabolic biomarker improvements, and reduce need for medications.
Why this rating
Based on the Look AHEAD trial, which is a large RCT.
Source
Weight-Loss Intervention by Telephone: Lessons Learned
Judith Wylie‐Rosett · Diabetes Care · 2014
DOI 10.2337/dc14-0628
otherCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A sustained weight loss of 3–5% is likely to result in clinically meaningful reductions in triglycerides, blood glucose, and A1C.Strong
- Achieving more weight loss (∼10%) will reduce blood pressure, improve LDL cholesterol and HDL cholesterol, and reduce the need for medications required to control cardiometabolic risk.Strong
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