Research
Metabolic adaptation
Reductions in fat mass (FM) by 10% are associated with a lower risk of kidney outcomes (adjusted HR 0.80, 95% CI 0.69-0.94) in participants with overweight/obesity and type 2 diabetes mellitus (T2DM) in the intensive lifestyle intervention group.
Practitioners should consider promoting fat loss as a strategy to reduce kidney disease risk in patients with T2DM.
StrongSupportsmedium confidence
In the intensive lifestyle intervention (ILI) group, reductions in FM (per 10% decrease, adjusted hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.69-0.94) ... were significantly associated with a lower risk of kidney outcomes.
Why this rating
Based on a post hoc analysis of a large RCT (Look AHEAD trial).
Source
Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus
Cheng Zu et al. · Diabetes Obesity and Metabolism · 2024
cohortCited 6×
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