Research
Metabolic adaptation
Reductions in waist circumference (WC) by 10% are associated with a lower risk of kidney outcomes (adjusted HR 0.72, 95% CI 0.59-0.88) in participants with overweight/obesity and T2DM in the intensive lifestyle intervention group.
Practitioners should encourage reductions in waist circumference to help lower kidney disease risk in T2DM patients.
StrongSupportsmedium confidence
In the intensive lifestyle intervention (ILI) group, ... reductions in WC (per 10% decrease, adjusted HR 0.72, 95% CI 0.59-0.88) ... were significantly associated with a lower risk of kidney outcomes.
Why this rating
Based on a post hoc analysis of a large RCT (Look AHEAD trial).
Source
Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus
Cheng Zu et al. · Diabetes Obesity and Metabolism · 2024
cohortCited 6×
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