Research
Energy balance
Changes in lean mass (LM) are not significantly associated with the risk of kidney outcomes (adjusted HR 0.78, 95% CI 0.58-1.06) in participants with overweight/obesity and T2DM.
Practitioners may not need to prioritize lean mass changes for kidney health in T2DM patients.
StrongRefutesmedium confidence
The change in LM was not significantly associated with risk of kidney outcomes (per 10% decrease, adjusted HR 0.78, 95% CI 0.58-1.06).
Why this rating
Based on a post hoc analysis of a large RCT (Look AHEAD trial).
Source
Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus
Cheng Zu et al. · Diabetes Obesity and Metabolism · 2024
DOI 10.1111/dom.15699
cohortCited 6×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Reductions in fat mass (FM) by 10% are associated with a lower risk of kidney outcomes (adjusted HR 0.80, 95% CI 0.69-0.94) in participants with overweight/obesity and type 2 diabetes mellitus (T2DM) in the intensive lifestyle intervention group.Strong
- Reductions in waist circumference (WC) by 10% are associated with a lower risk of kidney outcomes (adjusted HR 0.72, 95% CI 0.59-0.88) in participants with overweight/obesity and T2DM in the intensive lifestyle intervention group.Strong
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →