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Single-set resistance training performed to failure elicits greater hypertrophy gains compared to submaximal effort, although differences are modest.
Practitioners may consider incorporating training to failure for enhanced muscle growth.
StrongSupportsmedium confidence
Several measures of hypertrophy tended to favor FAIL, although absolute differences between conditions were generally modest.
Why this rating
Based on the randomized controlled trial design.
Source
Without Fail: Muscular Adaptations in Single-Set Resistance Training Performed to Failure or with Repetitions-in-Reserve
Thomas Hermann et al. · Medicine & Science in Sports & Exercise · 2025
DOI 10.1249/mss.0000000000003728
rct · n=42Cited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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