Research
Cellular
GLP-1 RA use was associated with a higher risk of gastroparesis (HR 1.591, P < 0.001) and intussusception (HR 1.383, P = 0.025) compared with oral antidiabetic therapy.
Clinicians should monitor patients on GLP-1 RAs for signs of gastroparesis and intussusception.
StrongSupportsmedium confidence
GLP-1 RA use was associated with a higher risk of gastroparesis (HR 1.591, P < 0.001) and intussusception (HR 1.383, P = 0.025) compared with oral antidiabetic therapy.
Why this rating
Based on a large retrospective cohort study design.
Source
Gastrointestinal and Hepatobiliary Safety of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes
Chengu Niu et al. · The American Journal of Gastroenterology · 2025
DOI 10.14309/ajg.0000000000003760
cohort · n=460830Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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