Research
Cellular
GLP-1 receptor agonists (GLP-1RAs) may influence skeletal muscle through anti-inflammatory, antioxidant, and mitochondrial-supportive mechanisms.
Practitioners should consider the potential muscle-preserving effects of GLP-1RAs in patients at risk for sarcopenia.
StrongSupportsmedium confidence
emerging preclinical evidence suggests that GLP-1RAs may directly and indirectly influence skeletal muscle through anti-inflammatory, antioxidant, and mitochondrial-supportive mechanisms.
Why this rating
Based on findings from large-scale trials and preclinical evidence mentioned in the abstract.
Source
Glucagon-like peptide-1 receptor agonists and muscle health: potential role in sarcopenia prevention and treatment
Ainhoa González-Luis et al. · European Journal of Endocrinology · 2025
DOI 10.1093/ejendo/lvaf223
reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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