Browse the evidence

Common side effects of all GLP-1-agonists include an increased risk of gastrointestinal and gallbladder-related complaints.

Clinicians should be aware of potential gastrointestinal and gallbladder-related side effects when prescribing GLP-1-agonists.

Anti-obesity vaccines face significant immunological and regulatory challenges.

Understanding these challenges is crucial for developing effective anti-obesity vaccines.

The most common adverse reactions associated with tirzepatide are gastrointestinal disorders.

Healthcare providers should inform patients about potential gastrointestinal side effects when prescribing tirzepatide.

If not detected and treated early, MASLD can progress to fibrosis and hepatocellular carcinoma.

Early detection and treatment of MASLD are crucial to prevent serious complications.

Tirzepatide reverses β-cell dedifferentiation in HFD-fed mice.

Tirzepatide may help restore β-cell function by reversing dedifferentiation in diabetic conditions.

GLP-1 RA-induced gastroparesis can increase the risk of aspiration during ophthalmic surgery.

Surgeons should be aware of the aspiration risk in patients using GLP-1 RAs.

GLP-1R agonists can improve cardiac contractility in human hearts.

Practitioners may consider GLP-1R agonists as a potential treatment to enhance heart contractility.

Epicardial adipose tissue may contribute to arrhythmogenesis through pro-inflammatory and pro-fibrotic effects.

Addressing epicardial adipose tissue may be important in managing arrhythmias in obese patients.

Dietary protein intake did not affect daily myofibrillar protein synthesis rates during immobilization.

Practitioners should note that increasing dietary protein may not mitigate muscle loss during short-term disuse.

Gastric bypass surgery performed without division of the mesentery significantly reduces postoperative complications such as leakage and ulceration/stenosis.

Surgeons should consider the intact mesentery technique to minimize complications.

Adipositas ist eine multifaktorielle Erkrankung mit global steigender Prävalenz.

Practitioners should recognize the multifactorial nature of obesity when addressing it in patients.

Supercentenarians can withstand serious/fatal illnesses more than their peers and have a decreased aging rate.

Understanding the resilience of supercentenarians can inform health strategies for aging populations.

Supercentenarians develop symptoms of degenerative diseases 20–30 years later than the general population.

This insight can help in understanding the aging process and developing interventions.

Machine learning can be incorporated into Precision Nutrition research with high performance.

Practitioners should consider using machine learning techniques to enhance precision nutrition strategies.

Dietary fatty acids modify fluidity and key physiological functions in plasma membranes.

Understanding the role of fatty acids can help in dietary planning for cardiovascular health.

Wash-in and washout effects can threaten the validity of short-term dietary trials.

Researchers should consider the timing of interventions and outcomes in dietary trials to ensure validity.

Type 2 Diabetes Mellitus (T2DM) is characterized by tissue insulin resistance and loss of pancreatic β cell function.

Understanding the nature of T2DM is crucial for effective management strategies.

The term 'prediabetes' does not adequately describe the cellular changes occurring in individuals with dysglycemia.

Awareness of the limitations of the term 'prediabetes' can improve clinical understanding.

Highly unsaturated fatty acids (HUFA) have n-3 and n-6 motifs with documented differences in intensity of destabilizing positive feedback loops amplifying pathophysiology.

Understanding the role of HUFA can inform dietary recommendations for cardiovascular health.

The quality improvement case study provides important lessons for transforming patient-physician-practice support systems.

Health systems can learn from this case study to improve patient engagement and care.

Improving health and care as described by the Quadruple Aim requires innovation at the front lines of clinical care.

Practitioners should seek innovative approaches to enhance patient care.

Higher BMI was associated with a different airway shape, including larger minimum anteroposterior distance and smaller minimum lateral distance.

Understanding the changes in airway shape with BMI can help tailor OSA treatment strategies.

A better understanding of antidiabetic drugs' effects on skeletal muscle lipid metabolism is needed.

Future research should prioritize understanding how antidiabetic drugs affect lipid metabolism in skeletal muscle.

Obesogenic stimuli promote adipose tissue macrophages to recruit neutrophils from the bone marrow in mice.

Understanding neutrophil recruitment can inform strategies to manage inflammation in obesity.