Research
Cellular
GLP-1R agonists can improve cardiac contractility in human hearts.
Practitioners may consider GLP-1R agonists as a potential treatment to enhance heart contractility.
StrongSupportsmedium confidence
We discuss here the acute contractile effects of such agonists on isolated human atrial and ventricular cardiac preparations from failing and non-failing hearts.
Why this rating
The study discusses both experimental and clinical data.
Source
Acute Contractile Effects of Glucagon-like-Peptide-1 Receptor Agonists in the Human Heart
Joachim Neumann et al. · Pharmaceutics · 2026
DOI 10.3390/pharmaceutics18040447
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Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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