Browse the evidence

Inhibiting neutrophil recruitment out of the bone marrow in obese mice or during weight loss reduces bone marrow myelopoiesis and adipose tissue inflammation.

Targeting neutrophil recruitment may help reduce inflammation during obesity management.

In humans with obesity, plasma neutrophil chemokines are increased and correlate with increased insulin resistance, but do not decrease with weight loss.

Monitoring neutrophil chemokines may provide insights into insulin resistance in obese patients.

Nitro-oleic acid (NO2-OA) treatment improves glucose tolerance in high fat diet (HFD)-fed Nrf2fl/fl mice but does not improve glucose tolerance in adipocyte-specific Nrf2 knockout (ANKO) mice.

NO2-OA may be effective for improving glucose tolerance in certain populations but not in those lacking Nrf2 in adipocytes.

Adipocyte-specific deletion of Nrf2 negates the protective effects of nitro-oleic acid on glucose tolerance.

Understanding the role of Nrf2 in adipocytes can inform strategies for managing glucose tolerance in obesity.

Diabetic nephropathy affects approximately 700 million people worldwide and is the leading cause of chronic kidney insufficiency.

Healthcare providers should be aware of the high prevalence of diabetic nephropathy in T2D patients.

Effective nephroprotection requires early identification of at-risk patients through screening.

Implement routine screening for CKD risk factors in clinical practice.

Cheeses improved C. elegans lifespan, mobility with aging, and age-related muscle degradation.

Incorporating these cheeses may support longevity and mobility in aging populations.

Diabetic neuropathy remains underdiagnosed and undertreated.

There is a need for improved screening and treatment protocols for diabetic neuropathy.

Participants with microvascular disease (MVD) have a 2.5-fold higher risk of incident heart failure (HF) than those without MVD.

Healthcare providers should monitor heart health closely in patients with MVD.

MitoQ supplementation did not impact mitochondrial respiration or H2O2 emission in the presence of ADP.

MitoQ does not enhance mitochondrial function during exercise in older adults.

MitoQ supplementation did not alter acute exercise-induced redox responses in skeletal muscle.

MitoQ does not affect redox signaling during acute exercise in older adults.

HbA1C levels increase alongside the duration of illness in individuals with type 2 diabetes.

Practitioners should monitor HbA1C levels to assess disease progression in diabetic patients.

Observational data suggest GLP-1 RAs improve walking distance in peripheral artery disease.

GLP-1 RAs may enhance mobility in patients with peripheral artery disease.

Nutritional therapists are too rarely consulted despite the significant effects of diet on cardiovascular risk factors.

Practitioners should consider involving nutritional therapists in treatment plans for dyslipidemias.

Tirzepatide may result in an increase in non-serious adverse events (risk ratio 1.33, 95% CI 1.03 to 1.71) compared to placebo.

Clinicians should monitor for non-serious adverse events when prescribing tirzepatide.

Incretin therapies could ameliorate fatty liver disease, chronic inflammation, sleep apnea, and possibly degenerative bone disorders and cognitive decline.

Incretin therapies may be considered for patients with these co-morbidities, pending further research.

Baseline disease severity, depressive symptoms, insulin resistance, and preperitoneal fat were negatively associated with PASI improvement.

Understanding these associations can help tailor treatment strategies for better outcomes.

Tirzepatide may have potential therapeutic effects on metabolic dysfunction-associated steatohepatitis (MASH).

Tirzepatide could be explored as a treatment option for patients with MASH, pending further research.

The relationship between weight modification after bariatric surgery and blood pressure measurement could provide insights into the mechanisms of organ damage associated with elevated blood pressure in obesity.

Further research is needed to explore the mechanisms of BP-related organ damage in obese patients post-surgery.

High bodyweight variability was significantly associated with an increased risk of psoriasis, with a hazard ratio of 1.06 (1.05-1.07) comparing the highest quartile (Q4) to the lowest quartile (Q1).

Clinicians should encourage patients to maintain stable bodyweight to help prevent psoriasis.

Mechanistic studies may explain the cardiovascular benefits of SGLT2 inhibition in T2DM patients.

Practitioners should consider the underlying mechanisms when evaluating the cardiovascular benefits of SGLT2 inhibitors.

Increased consumption of dietary supplements is significantly related to poor oral health among amateur bodybuilders and powerlifters.

Practitioners should be aware of the potential negative effects of dietary supplements on oral health in this population.

Amateur weightlifters and bodybuilders are a new risk group for developing dental caries.

Awareness and preventive measures should be implemented for this group to mitigate dental health risks.

Methods of oral hygiene reported by participants appear to be insufficient.

Improving oral hygiene practices is crucial for this population to prevent dental issues.