Research
Cellular
Adipocyte-specific deletion of Nrf2 negates the protective effects of nitro-oleic acid on glucose tolerance.
Understanding the role of Nrf2 in adipocytes can inform strategies for managing glucose tolerance in obesity.
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Herein, we reveal that protective effects of improved glucose tolerance by NO2-OA is absent when Nrf2 is specifically ablated in adipocytes (ANKO mice).
Why this rating
Based on study design from abstract.
Source
Adipocyte-specific Nrf2 deletion negates nitro-oleic acid benefits on glucose tolerance in diet-induced obesity
Dionysios V. Chartoumpekis et al. · Nitric Oxide · 2024
DOI 10.1016/j.niox.2024.06.002
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Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Nitro-oleic acid (NO2-OA) treatment improves glucose tolerance in high fat diet (HFD)-fed Nrf2fl/fl mice but does not improve glucose tolerance in adipocyte-specific Nrf2 knockout (ANKO) mice.Strong
- Nitro-oleic acid treatment does not alter body weight in Nrf2fl/fl and ANKO mice on both high fat diet (HFD) and low-fat diet (LFD).Strong
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