Browse the evidence

New imaging techniques may provide more accurate estimations of BAT mass in adults.

Improved imaging could enhance our understanding of BAT's role in metabolism.

Naltrexone, bupropion, or their combination (B-N) is not associated with the incidence of major cardiovascular adverse events (MACE) compared with placebo.

Clinicians can consider that these treatments do not increase the risk of major cardiovascular events.

The current evidence does not demonstrate Blautia’s direct involvement as a pathogenic microbe in obesity development or progression.

Practitioners should consider that Blautia may not be a direct target for obesity treatment based on current evidence.

Islet autoantibodies were present in 6.4% of overweight/obese adults with type 2 diabetes.

Practitioners should be aware that a small percentage of overweight/obese adults with type 2 diabetes may have islet autoantibodies.

Less than 25% of primary care physicians regularly refer patients for further management or track their weight-control behaviors over time.

Practitioners should note that many PCPs do not regularly refer or track weight management.

Access to new antiobesity medications is severely limited despite their potential to combat obesity.

Practitioners should be aware of the barriers to access for new antiobesity medications.

There are currently no completed randomized trials of physical activity where mortality is a prespecified primary outcome.

Current physical activity guidelines may lack robust evidence from randomized trials focused on mortality.

Increasing baseline blood-based biomarker levels were not associated with any cognitive composite z score.

Baseline BBM levels may not be useful for predicting cognitive function in this population.

Existing data analytic methods for SMARTs are suitable only for superiority testing.

Current analytic methods need to be adapted for noninferiority/equivalence testing in SMARTs.

Approximately two-thirds of patients who achieved remission relapsed within 1 year.

Practitioners should prepare for potential relapse in patients post-remission.

Obesity prevalence is projected to grow by 40% in the next decade.

Health professionals should prepare for increased obesity-related health issues.

Longitudinal studies of LIRE-BFR showed no changes in arterial stiffness in both young and older people.

Practitioners should note that LIRE-BFR may not affect arterial stiffness over the long term in their clients.

Nutrition is relevant along the criminal justice continuum.

Nutrition should be integrated into discussions and interventions within the criminal justice system.

Obesity prevalence is projected to grow by 40% in the next decade.

Health professionals should prepare for increased obesity-related health issues.

Meta-analysis is commonly used in sport and exercise science to synthesize empirical studies.

Practitioners should consider using meta-analysis to inform their understanding of empirical studies.

Loss-of-function mutations in the genes encoding POMC, MC3R, and MC4R can lead to early-onset obesity and developmental dysregulation.

Understanding these mutations can inform treatment strategies for obesity.

1,260,969 (8.5%) Black people and 4,989,919 (4.7%) non-Black people had ≥CKD stage 3 according to the 2021 CKD-EPI formula.

Practitioners should consider the impact of the new eGFR formula on the classification of CKD in patients when prescribing antiobesity medications.

Obesity affects around 40% of adults in the United States.

Health practitioners should be aware of the high prevalence of obesity in the adult population.

Obesity accounts for $172.74 billion in annual expenditures in the United States.

Understanding the economic burden of obesity can inform healthcare policy and resource allocation.

Obesity alone did not emerge as a robust predictor of major adverse cardiovascular events (MACEs).

Obesity should not be solely relied upon as a risk factor in cardiovascular assessments.

The effectiveness of nutrigenomics and lifestyle genomics interventions for weight management in clinical practice cannot yet be conclusively determined.

Practitioners should be cautious in applying nutrigenomic interventions for weight management until more conclusive evidence is available.

Low-volume exercise programs, regardless of their intensity, do not change CRP levels in women with central obesity.

Practitioners should note that low-volume exercise may not be effective for reducing inflammation in this population.

There was no association between CRP levels and other pre-intervention variables.

Practitioners should consider that other factors may not influence CRP levels in this population.

Mean blood pressures were within normal limits.

Counseling may help maintain normal blood pressure levels.