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84.3% of participants on semaglutide achieved a 5% or greater body weight reduction compared to 17.2% on placebo.

A high proportion of patients on semaglutide can expect significant weight loss.

R-ESG offered higher total body weight loss (TBWL%) than GLP1/GIP-RA at 3 months (11.2% vs. 4.3%, p < .001), 6 months (13.5% vs. 6.8%, p < .001), and 12 months (13.4% vs. 9.2%, p = .07).

Practitioners may consider R-ESG as a more effective option for weight loss in patients experiencing weight recidivism after sleeve gastrectomy.

GLP1/GIP-RA achieved significantly lower TBWL% in patients with prior SG compared to those with intact stomach at 3 months (4.3% vs. 5.7%, p = .02), 6 months (6.8% vs. 9.2%, p = .02), and 12 months (9.2% vs. 12.7%, p = .03).

Practitioners should be aware that GLP1/GIP-RA may be less effective for weight loss in patients with prior sleeve gastrectomy compared to those with intact stomachs.

Moderate-to-vigorous physical activity (MVPA) is inversely associated with all-cause mortality in individuals with type 2 diabetes.

Encourage patients with type 2 diabetes to engage in regular MVPA to reduce mortality risk.

Consuming protein supplements with meals may more effectively promote weight control and reduce fat mass compared to consuming them between meals.

Practitioners should consider recommending protein supplements with meals for better fat loss outcomes.

A higher percentage of individuals consuming protein supplements between meals showed increases in body mass compared to those consuming with meals.

While body mass may increase with protein between meals, it is essential to consider overall body composition goals.

Lorcaserin, phentermine with topiramate, bupropion with naltrexone, and liraglutide have proven effects on reducing weight in patients with type 2 diabetes and obesity.

Practitioners can consider these medications for weight management in diabetic patients.

Phentermine with topiramate is the most efficacious medication for weight loss among the studied antiobesity medications.

Phentermine with topiramate may be prioritized for weight loss in diabetic patients.

Pharmacists can effectively evaluate and monitor the use of GLP-1 therapy in weight management patients.

Utilizing pharmacists in weight management can enhance patient care and therapy outcomes.

Patients receiving email-based health coaching and Semaglutide therapy lost a mean weight of 9.52% over 5 months.

Email-based coaching combined with Semaglutide can be effective for weight loss in overweight and obese patients.

81.51% of the cohort lost a 'meaningful' amount of weight (5% or more).

A high percentage of participants achieved significant weight loss, indicating the program's effectiveness.

The 'food labels & real-time feedback' and 'ordering' strategies had significantly positive main effects on overall diet quality of the shopping basket.

Implementing food labels with real-time feedback and ordering by nutritional quality can significantly enhance diet quality in online grocery shopping.

Combining 'food labels & real-time feedback' and 'ordering' interventions is more effective than using either intervention alone.

Using a combination of food labels with real-time feedback and ordering can significantly enhance diet quality in online grocery shopping.

Ad libitum energy intake was 689±73 kcal/d lower during the plant-based, low-fat diet compared to the animal-based, ketogenic diet (p<0.0001).

Practitioners may consider recommending a plant-based, low-fat diet for better appetite control and lower energy intake.

Individuals with greater weight loss reported consuming higher proportions of low-energy-dense foods and lower proportions of high-energy-dense foods than individuals with less weight loss at 4 months and 18 months.

Encouraging the consumption of low-energy-dense foods may enhance weight loss outcomes.

At 18 months, individuals with greater weight loss had higher fruit and vegetable intake, dietary quality, nutrition knowledge, and healthier food choice.

Improving nutrition knowledge and food choices may support weight loss efforts.

Being in the top versus bottom quartile of the carbohydrate quality index (CQI) is associated with a higher nutrient adequacy ratio (NAR) for folic acid (OR: 3.20), vitamin A (OR: 3.66), magnesium (OR: 5.94), and vitamin C (OR: 7.85).

Practitioners should consider promoting higher carbohydrate quality to improve micronutrient intake among adults.

Increasing the consumption of total fiber and solid carbohydrates while decreasing the glycemic index can improve micronutrient intake adequacy.

Dietary interventions should focus on fiber and solid carbohydrate intake to enhance micronutrient adequacy.

A healthy lifestyle is essential for the long-term success of any therapeutic intervention for obesity.

Encouraging lifestyle changes is vital for effective obesity treatment.

All groups showed significant improvements in cardiorespiratory fitness, upper body strength, lower body strength, and 2000m rowing performance.

Concurrent training can lead to significant improvements in fitness and strength regardless of protein supplementation.

Physical activity should be promoted as a foundational component of care for patients receiving NuSH-based treatments for obesity.

Encourage physical activity as part of a comprehensive treatment plan for obesity.

Roux-en-Y gastric bypass (RYGB) surgery is the most effective intervention for weight loss.

RYGB should be considered for patients seeking significant weight loss.

Patients with type 2 diabetes mellitus (T2DM) who followed a 3-month partial meal replacement plan achieved an average weight loss of 7.1±7.0kg at 12 months and 4.2±7.7kg at 24 months.

Implementing a partial meal replacement plan may aid in weight loss for patients with T2DM.

The three isocaloric eating patterns, differing in carbohydrate cellularity and amount, decreased visceral fat volume significantly and to a similar clinically relevant degree.

Practitioners can consider various isocaloric diets for reducing visceral fat in obese patients.