Browse the evidence

Tirzepatide was recently approved by the FDA for the management of type 2 diabetes.

Tirzepatide can be utilized in clinical settings for managing type 2 diabetes, with potential implications for weight loss.

Metabolic and bariatric surgery is independently associated with a lower risk of incident cancer than nonsurgical obesity care.

Practitioners should consider metabolic and bariatric surgery as a viable option for reducing cancer risk in obese patients.

Among patients with monthly counseling or more, the 10-year cumulative incidence of death and cardiovascular events was 33.0% compared with 38.1% for less than monthly counseling.

Practitioners should consider increasing the frequency of lifestyle counseling for diabetic patients to improve long-term outcomes.

Higher frequency of lifestyle counseling was associated with lower incidence of death and cardiovascular events.

Increasing lifestyle counseling frequency may lead to better health outcomes for diabetic patients.

No significant differences in adverse events were observed between semaglutide and comparator groups.

This suggests that semaglutide is as safe as other treatments in terms of adverse events.

Fifty-six studies reported statistically significant findings in outcome measures.

Interventions can lead to measurable improvements in health outcomes.

The large reported diet effects on energy expenditure were influenced by excessive amounts of unaccounted energy.

Accurate energy accounting is crucial for understanding diet effects on energy expenditure.

There were no significant differences between groups for the remaining outcomes, although a small effect size favoring TRAD was observed for the middle region of the pectoralis major (g = -0.25).

Practitioners should note that while TRAD may have a slight advantage, it is not statistically significant for all outcomes.

Considering interactions among dietary components can help reconcile different models of obesity.

Practitioners should consider dietary interactions when developing obesity interventions.

PA at months 2 to 4 was significantly correlated with PA at 1 year (rs = .29-.35, P < .01).

Early engagement in physical activity can predict long-term adherence.

Reductions in fat mass were similar across all protein intake groups, with LP, MP, and HP showing reductions of 1.7%, 3.7%, and 3.1% respectively (P > 0.05).

Fat loss outcomes may not significantly differ based on protein intake levels in older women undergoing resistance training.

Tirzepatide achieved similar 12-month TBWL% as R-ESG (13.2% vs. 13.4%, p = .9) and significantly more than semaglutide (13.2% vs. 8.1%, p = .04).

Tirzepatide may be a viable alternative for weight loss in patients post-sleeve gastrectomy, potentially outperforming semaglutide.

The policy of Nutrition Facts added-sugar labeling is associated with a reduction of 30,000 new cancer cases and 17,100 cancer deaths among US adults over a lifetime.

Implementing added-sugar labeling could significantly reduce cancer incidence and mortality.

The policy is associated with a gain of 116,000 quality-adjusted life-years (QALYs) among US adults.

The policy could lead to significant improvements in life quality and longevity.

Additional industry reformulation to reduce added-sugar amounts would double the impact of the policy.

Encouraging food industry reformulation could significantly enhance public health outcomes.

Both FDA-approved gastric balloon systems (gas-filled IGB and fluid-filled IGB) had the same effectiveness in terms of percent total body weight loss at balloon removal.

Both balloon systems can be considered equally effective for weight loss.

The implementation of a pharmacist-led weight management clinic resulted in an estimated cost savings of $101,985.66.

Pharmacist involvement can lead to significant cost savings in weight management programs.

Discontinuation rates were strongly associated with copayment amount, increasing from 41% in the lowest quintile to 51% in the highest quintile.

Financial considerations significantly impact patient adherence to semaglutide treatment.

A higher carbohydrate quality index (CQI) is associated with greater micronutrient consumption adequacy in Iranian adults.

Encouraging higher CQI may enhance overall nutrient adequacy in dietary practices.

Minimally invasive bariatric surgeries, endoscopic procedures, fecal microbiota transplants (FMTs), and pharmaceuticals like GLP-1 receptor agonists show promising results for obesity treatment.

Practitioners should consider these innovative treatment options for obesity management.

Bariatric surgery is the most cost-effective definitive treatment for all classes of obesity.

Healthcare systems should prioritize bariatric surgery as a treatment option for obesity.

Participants enrolling during program periods with access to a larger number of stores had ≤14.5% absolute higher redemption rates and 5-fold greater likelihood of shopping each month than those enrolled with fewest locations.

Increasing the number of stores available for produce prescription programs may enhance redemption rates and shopping frequency.

Redemption rates increased over time for participants in the program, rising from 31% in month 1 to 88% in month 24.

Longer participation in produce prescription programs is associated with significantly higher redemption rates.

There is a strong need for multimodal therapeutic approaches to address obesity.

Therapists should implement diverse strategies to effectively manage obesity.