Browse the evidence

Adherence to the Mediterranean diet is associated with improved control of cardiovascular risk factors.

Encouraging adherence to the Mediterranean diet may help improve cardiovascular health in diabetic patients.

Intermittent energy restriction methodologies such as refeeds and diet breaks may improve fat loss efficiency, lean body mass retention, and attenuate metabolic adaptation to weight loss.

Practitioners may consider incorporating refeeds and diet breaks into competition preparation strategies.

Weight-lowering approaches such as bariatric surgery and treatment with semaglutide and tirzepatide can alleviate both cardiovascular diseases (CVD) and nonalcoholic fatty liver disease (NAFLD).

Practitioners should consider weight loss interventions as effective strategies for managing NAFLD and CVD.

A minimal amount of weight loss can resolve NAFLD in lean patients.

Even small weight loss should be encouraged in lean patients with NAFLD for potential resolution of the condition.

Obesity significantly increases the risk of both nonalcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD).

Addressing obesity is crucial for reducing the risk of NAFLD and CVD in patients.

Exercise is a key component of lifestyle therapy for prevention and treatment of diabetes.

Practitioners should incorporate exercise into diabetes management plans.

Diets that restrict certain macronutrients may be better for controlling weight and metabolic risk factors.

Consider advising patients on diets with specific macronutrient restrictions for better outcomes.

Exercise is a well-established measure to prevent or mitigate the adverse consequences of obesity.

Encouraging exercise can be a key strategy in obesity management.

Diets that restrict certain macronutrients may be better for controlling weight and metabolic risk factors.

Consider exploring macronutrient-restricted diets for better weight and metabolic control in patients.

Rest interval durations of 60 seconds and 120 seconds between sets favored a higher total load lifted in the exercise session compared to the 30 seconds rest interval.

Practitioners should consider longer rest intervals (60-120 seconds) to maximize load lifted during resistance training.

Intensive lifestyle interventions (ILIs) are preferred over anti-hyperglycemic medications for the prevention of type 2 diabetes (T2D) due to their safety, efficacy, and cost.

Practitioners should prioritize ILIs for T2D prevention in overweight/obese patients.

Offering intensive lifestyle interventions to all overweight/obese adults who volunteer for weight loss treatment may be a more effective approach to prevent type 2 diabetes.

Consider broadening eligibility for ILIs to enhance participation in weight loss programs.

Physical activity protects against type-2 diabetes through its positive effects on weight management and metabolic pathways involved in glycemic control that are not weight-dependent.

Encouraging physical activity can be a key strategy in diabetes prevention and management.

Participants with higher adherence scores for an overall low-carbohydrate diet (LCD) exhibited lower odds of hepatic steatosis (OR = 0.76, 95% CI: 0.61-0.96, p trend = 0.049).

Encouraging adherence to low-carbohydrate diets may reduce the risk of hepatic steatosis.

Replacing 5% of the energy from carbohydrates with total fat and protein is associated with lower steatosis prevalence (OR = 0.91, 95% CI: 0.83-0.99).

Modifying carbohydrate intake by increasing fat and protein may help lower the risk of hepatic steatosis.

For every pound of weight lost, there was a 0.02-point reduction on the HbA1C measured at the end of the RPM.

Practitioners can use weight loss as a target to help improve HbA1C levels in T2D patients.

Excess adiposity is associated with worse outcomes in breast cancer survivors.

Practitioners should consider addressing excess adiposity in breast cancer survivors to improve health outcomes.

Excess adiposity can be targeted to improve breast cancer outcomes.

Interventions aimed at reducing excess adiposity may enhance survivorship and quality of life for breast cancer survivors.

Tirzepatide-associated improvements in cardiometabolic risk factors are positively related to the degree of weight reduction.

Weight reduction through tirzepatide can lead to significant improvements in cardiometabolic health.

Improvements in triglycerides, HDL cholesterol, LDL cholesterol, and non-HDL cholesterol were primarily observed after weight reductions greater than 10%.

Targeting a weight reduction of over 10% may be necessary for significant improvements in lipid profiles.

The steepest improvements in cardiometabolic risk factors occurred between less than 5% and less than 20% weight reduction.

Practitioners should note that even modest weight loss can lead to significant health improvements, particularly within the 5-20% range.

A higher percentage of individuals consuming protein supplements with meals showed an increase in the ratio of lean mass to fat mass over time compared to those consuming between meals.

Encouraging protein consumption with meals may enhance body composition improvements.

Exercise positively impacts glycemic control and improves insulin sensitivity in diabetic patients.

Encouraging exercise can be an effective strategy to improve glycemic control in diabetic patients.

Lifestyle modifications have shown to prevent the progression to type 2 diabetes mellitus.

Practitioners should emphasize lifestyle modifications for diabetes prevention.