Browse the evidence

Common complications associated with GLP-1 RA treatment include nausea, constipation, abdominal pain, and vomiting.

Healthcare providers should monitor patients for these common side effects when prescribing GLP-1 RA.

Egg yolk intake does not further enhance muscle mass compared to egg whites in high-protein diets.

For those on high-protein diets, egg yolks may not provide additional muscle mass benefits over egg whites.

ω-3-PL/FFA was well tolerated with a safety profile similar to that of placebo.

Practitioners can confidently recommend ω-3-PL/FFA as a safe option for patients.

Obstructive sleep apnea is a common comorbidity in individuals with obesity.

Healthcare providers should be aware of the high prevalence of obstructive sleep apnea in obese patients.

GIP accounts for 60% to 80% of the postprandial insulin response.

Understanding GIP's role can help in managing postprandial insulin levels.

GIP is overexpressed in obese individuals, which may exacerbate insulin resistance.

Addressing GIP levels may be important in treating obesity-related insulin resistance.

85% of adolescents report no physical activity.

Strategies are needed to promote physical activity among adolescents.

There were no differences in antioxidant capacity markers and protein oxidation adducts between the traditional and pyramid training groups.

Both training systems are equally effective in improving oxidative stress markers.

Higher levels of circulating behenic acid are associated with a 15% lower risk of unhealthy aging events.

Practitioners may consider monitoring behenic acid levels as a potential marker for healthy aging.

Higher levels of circulating lignoceric acid are associated with a 16% lower risk of unhealthy aging events.

Practitioners may consider monitoring lignoceric acid levels as a potential marker for healthy aging.

The study highlights the need to explore determinants of circulating very-long-chain saturated fatty acids (VLSFAs) for promoting healthy aging.

Practitioners and researchers should consider investigating VLSFAs further to enhance strategies for healthy aging.

Within the diabetes support and education (DSE) group, cardiovascular disease outcomes did not differ.

DSE alone may not be sufficient to impact cardiovascular outcomes compared to intensive lifestyle interventions.

Baseline HbA1c levels were associated with reduced odds of type 2 diabetes remission after bariatric surgery (pooled difference in means = -1.05, 95% CI = -1.48 to -0.62, p < .001).

Practitioners should monitor HbA1c levels as they may indicate lower chances of remission post-surgery.

Fasting plasma glucose (FPG) levels were associated with reduced odds of type 2 diabetes remission after bariatric surgery (pooled standardized mean difference = -0.42, 95% CI: -0.64 to -0.20, p < .004).

Practitioners should consider FPG levels as a factor that may negatively impact remission rates post-surgery.

The safety profile of tirzepatide was broadly similar across BMI and age subgroups, but drug discontinuation due to adverse events was higher in participants aged ≥ 65 years.

While generally safe, practitioners should monitor older patients closely when prescribing tirzepatide.

Disparities in the use of SGLT-2 inhibitors and GLP-1 receptor agonists exist based on race, sex, and socioeconomic status.

Efforts should be made to address these disparities in prescribing practices.

The American and European guidelines have similar approaches to CVD prevention but also have some differences.

Clinicians should be aware of both similarities and differences in guidelines for tailored patient care.

Stable isotope tracers have significantly advanced the understanding of muscle protein turnover.

Utilizing stable isotope tracers can enhance research and understanding of muscle protein metabolism.

Systolic blood pressure was not statistically different between traditional resistance training (RT) and high velocity resistance training (HVRT) at the beginning and during 30 minutes after sessions.

Both training modalities may be equally effective in managing systolic blood pressure in this population.

There were no differences for psychophysiological variables between traditional resistance training (RT) and high velocity resistance training (HVRT).

Practitioners can expect similar psychophysiological outcomes from either training modality in this demographic.

Traditional recommendations for obesity treatment are largely ineffective.

Practitioners should be aware that traditional methods may not yield results.

There has been a revolution in understanding the molecular and neural control of appetite and body weight.

Understanding these mechanisms can inform treatment strategies for obesity.

C-reactive protein levels decreased after one year of GLP1-RA treatment.

Monitoring C-reactive protein levels may help assess the effectiveness of GLP1-RA in IBD.

23% of participants reported any adverse event while using GLP-1RAs, with 7% discontinuing treatment.

While GLP-1RAs are generally well-tolerated, practitioners should monitor for adverse events.