Browse the evidence

Mitochondrial uncoupling promotes energy dissipation and may serve as a strategy for obesity treatment.

Practitioners may consider mitochondrial uncoupling as a potential target for obesity interventions.

Observational data show a reduction in all-cause mortality and cancer risk in patients who have undergone bariatric surgery.

Bariatric surgery may significantly improve long-term health outcomes and reduce mortality risk.

Obesity is a chronic multifactorial disease.

Understanding obesity as a multifactorial disease is crucial for effective treatment.

Sustained significant weight loss through lifestyle changes is difficult for people with obesity in the long term.

Practitioners should be aware of the challenges faced by patients in achieving long-term weight loss.

HEC-CG115 led to more weight loss than semaglutide in diet-induced obese model mice.

HEC-CG115 may be a more effective option for weight loss in obese patients compared to semaglutide.

Performing additional sets of resistance exercise does not inherently result in greater increases in muscle size compared to lower volumes.

Practitioners should not assume that increasing the number of sets will always lead to greater muscle growth.

There has been limited success in curbing the incidence of T2D despite lifestyle modification being standard care.

Practitioners should recognize the barriers to effective lifestyle interventions.

The current evidence is insufficient to establish ingestion recommendations for protein hydrolysate supplementation.

Practitioners should be cautious in making specific recommendations for protein hydrolysate intake until more evidence is available.

Total protein intake was inversely related to lean mass in females only (Lean mass index: β= −0.84, Appendicular lean mass index: β= −0.35).

Practitioners should be cautious about recommending high total protein intake for females aiming to preserve lean mass.

Gastric bypass patients had an 85% lower risk of developing type 2 diabetes compared to non-operated patients with obesity during the first six years of follow-up.

Gastric bypass surgery significantly reduces the risk of type 2 diabetes in obese patients, especially in the first six years post-surgery.

The incidence of type 2 diabetes among non-operated patients with obesity was 11.7% during the follow-up period.

Non-operated obese patients have a high incidence of type 2 diabetes, highlighting the need for effective interventions.

The incidence of type 2 diabetes among gastric bypass patients was comparable to that of the general population.

Gastric bypass surgery can reduce diabetes risk to levels similar to those in the general population, indicating its effectiveness.

Chronic alterations in blood pH have a modifiable effect on whole body, muscle, and albumin protein kinetics.

Practitioners should consider the impact of blood pH on protein metabolism in dietary planning.

Leucine oxidation is negatively correlated with blood pH.

Understanding this correlation may help in managing dietary amino acid intake.

The study utilized a 2-way ANOVA with Tukey’s post hoc comparison to evaluate differences between groups.

The statistical methods indicate a rigorous approach to analyzing the data.

DXA-derived lean mass, BIA-derived skeletal muscle mass, and BodPod-derived fat-free mass overestimate D3-Cr-derived skeletal muscle mass.

Practitioners should be cautious of overestimations when using these common body composition assessment methods.

DXA, BIA, and ultrasound-derived appendicular lean mass uniformly underestimate D3-Cr-derived skeletal muscle mass by approximately 2.50 kg.

Practitioners should consider the potential underestimation when using these methods for assessing appendicular lean mass.

Food-related information is distributed across functionally distinct brain networks which act as opponent processes involved in guiding food-related behavior.

Understanding the distinct brain networks involved in food-related behavior can inform strategies for dietary interventions.

The inferred healthfulness or artificiality of foods is the greatest factor underlying similarity judgments, most strongly represented within the Prefrontal network.

Recognizing the impact of perceived healthfulness on food choices can aid in dietary planning.

The response to food images in the Prefrontal network is modulated strongly by judgments of the self-control required to resist eating those foods.

Understanding how self-control influences neural responses can help in developing strategies for better dietary choices.

No significant changes were found in body mass (BM) between linear training (LT) and undulating periodization (UP) groups after 8 weeks.

Both training protocols did not lead to significant changes in body mass for untrained older adults.

No significant changes were found in fat mass (FM) between linear training (LT) and undulating periodization (UP) groups after 8 weeks.

Both training protocols did not lead to significant changes in fat mass for untrained older adults.

No significant changes were found in fat-free mass (FFM) between linear training (LT) and undulating periodization (UP) groups after 8 weeks.

Both training protocols did not lead to significant changes in fat-free mass for untrained older adults.

PA may not be a critical factor influencing weight maintenance in PWD.

Weight maintenance strategies for PWD may need to consider factors beyond just physical activity.