Browse the evidence

Tirzepatide effectively attenuated the rewarding properties of alcohol, measured through locomotor stimulation, conditioned place preference, and accumbal dopamine release.

Tirzepatide may be a potential treatment for reducing alcohol consumption and its rewarding effects.

18F-FDG PET scanning is the most commonly used imaging modality to detect and quantify human BAT activity in vivo.

Clinicians can utilize 18F-FDG PET for assessing BAT activity in patients.

Alternative PET tracers and novel techniques have improved understanding of human BAT physiology.

Emerging imaging techniques can enhance research and clinical understanding of BAT's role in health.

Plasma GLP-1 and PYY responses do not differ between individuals with obesity and lean controls.

This suggests that obesity does not affect the immediate hormonal response of GLP-1 and PYY to a meal.

Tissue concentrations and mRNA expression of GLP-1 and PYY do not differ between individuals with obesity and lean controls.

This indicates that obesity does not alter the local production of GLP-1 and PYY in the gut.

GLP-1 medicines may suppress tumorigenesis through various mechanisms.

Further research is needed to understand the mechanisms by which GLP-1 medicines may affect tumorigenesis.

GLP-1 RA therapy was associated with a low rate of major adverse events in LVAD patients.

GLP-1 RA appears to be a safe adjunct therapy for LVAD patients.

Individuals with Friedreich's ataxia (FRDA) have lower insulin sensitivity (whole-body insulin sensitivity index 2.8 vs 5.3, P < .01) compared to controls.

Practitioners should be aware that FRDA is associated with reduced insulin sensitivity, which may impact metabolic health.

Ongoing research is crucial to confirm the long-term safety, effectiveness, and clinical role of these agents.

Practitioners should stay updated on research developments regarding these oral agents.

GLP-1 RA therapy was not associated with increased incidence of GI cancers.

GLP-1 RAs may be a safer option regarding GI cancer risk for patients with type 2 diabetes.

No significant differences were observed in biliary cancer or hepatocellular carcinoma between GLP-1 RAs and other oral antidiabetic medications.

Clinicians can consider GLP-1 RAs without increased concern for biliary or liver cancer risks.

Incidental exposure to incretin-based medications during early pregnancy is becoming more likely.

Clinicians should be aware of the risks of medication exposure in unplanned pregnancies.

Both drugs are associated with kidney and thyroid disorders.

Healthcare providers should monitor kidney and thyroid function in patients using these medications.

GLP-1RA development traces a century of translational progress from gut hormones to multi-agonist therapeutics.

Understanding the historical context can inform current therapeutic approaches.

None of the four glucagon-like peptide-1 receptor agonist (GLP-1RA) or glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RA therapies were cost-effective compared with lifestyle management.

Practitioners should consider lifestyle management as the most cost-effective option for treating obesity in this population.

Natural products from plants are a promising source for new lead structures for drug discovery targeting obesity.

Practitioners may consider exploring natural plant metabolites for obesity treatment.

No clinically relevant differences in generic health-related quality of life (HRQoL) were observed between sleeve gastrectomy and Roux-en-Y gastric bypass.

Clinicians can expect similar HRQoL outcomes from both surgical options for patients with severe obesity.

JMV-449 induced noticeable dose-dependent insulin-releasing actions in BRIN-BD11 beta-cells.

JMV-449 may be a promising agent for enhancing insulin secretion in diabetes treatment.

A new classification of patients with diabetes mellitus into clusters can assess the risk of developing diabetic nephropathy.

Practitioners can use this classification to better assess nephropathy risk in diabetic patients.

Systematic screening for advanced fibrosis related to MASLD is recommended for patients with T2D.

Healthcare professionals should implement systematic screening for liver fibrosis in diabetic patients.

Perioperative mortality for bariatric surgery averages 0.3% in accredited centers.

Practitioners can reassure patients about the low perioperative mortality risk in accredited facilities.

Change in accelerometry-measured MVPA at 1 year and self-reported change in PA at 1 and 4 years were not associated with CVD outcomes.

Self-reported PA changes may not be reliable indicators of CVD risk in this population.

The food industry generates close to $2 trillion in annual sales in the United States.

This indicates the significant economic impact of the food industry.

Food politics refers to how governments make decisions affecting food systems.

Understanding food politics is crucial for navigating food policy and industry dynamics.