Browse the evidence

The cost needed to treat per 1% of body weight reduction with tirzepatide is estimated at $985 compared with $1845 with semaglutide.

Tirzepatide is more cost-effective for achieving weight loss in this population.

The magnitude of effect of NNS substitution for added sugars has ranged from modest to null.

Practitioners should be aware that the effectiveness of NNS can vary significantly.

Existing data are insufficient to clearly support or refute the effectiveness of NNS substitution for reducing added sugar intake.

Practitioners should consider the current limitations of evidence when advising on NNS use.

Testosterone replacement therapy (TR) increased pubic hair in 72.7% of adult male patients with Prader-Willi syndrome.

Practitioners may consider TR as a viable option to enhance secondary sexual characteristics in this population.

Type 2 diabetes mellitus (T2DM) patients are at an increased risk for cardiovascular disease (CVD).

Healthcare providers should be aware of the increased cardiovascular risks in T2DM patients.

Trials integrating smartphone use exhibited significantly greater racial minority enrollment than trials that did not.

Incorporating smartphone technology in behavioral weight loss trials may enhance minority participation.

SGLT2 inhibitors reduce cardiovascular morbidity and mortality in patients with type 2 diabetes.

SGLT2 inhibitors can be considered in treatment plans to improve cardiovascular outcomes in diabetic patients.

SGLT2 inhibitors may slow the progression of chronic kidney disease in high-risk individuals with type 2 diabetes.

SGLT2 inhibitors should be considered for patients at risk of chronic kidney disease.

There was a trend towards greater muscle mass adaptations in the BFR-CH group, but these findings showed no statistical significance.

While BFR-CH may show promise, practitioners should be cautious as the results are not statistically significant.

Whey protein supplementation does not increase lean mass in studies without energy restriction.

Whey protein may not be effective for increasing lean mass without accompanying energy restriction.

Understanding the hedonic mechanisms mediated by gut peptide action could advance development of potential therapeutic strategies for the treatment of obesity and its comorbidities.

Research on gut peptides may lead to new obesity treatments.

PLIN3 protein content is associated with 24-hour respiratory quotient (RQ) and skeletal muscle-specific ex vivo palmitate oxidation.

Higher PLIN3 levels may enhance lipid oxidation in skeletal muscle, which could inform dietary and exercise recommendations.

Treatment with brefeldin A (BFA) reduces lipid oxidation in cells from lean and T2D individuals, but not in active participants.

BFA may be a useful tool for studying lipid metabolism, but its effects vary significantly among different metabolic states.

At any given body weight and body composition, there is quite a large variability in the resting metabolic rate.

Practitioners should consider individual variability in metabolic rates when assessing weight management strategies.

Metabolic rate after adjustment for body composition and body weight is a familial trait.

Genetic factors may play a significant role in metabolic rates, influencing weight management approaches.

Few studies reported long-term outcomes of technology-assisted interventions.

Researchers should focus on long-term outcomes in future studies.

Active GLP-1 RA prescription was associated with a significant reduction in postoperative hematoma (RR: 0.440; P = 0.023).

Consideration of GLP-1 RA may help in minimizing hematoma risks in surgical patients.

Interleukin 6 and 8 (IL-6 and IL-8), leukocyte-inducing factor, and connective tissue growth factor (CTGF) mRNA levels increased approximately 10-fold after a single exercise bout.

Exercise significantly increases the expression of certain myokines, which may influence muscle physiology.

Myostatin levels decreased after a single exercise bout.

Exercise may reduce myostatin levels, which could be beneficial for muscle growth.

Myokine expressions in myotubes from sedentary donors for CTGF and myostatin decreased, whereas IL-6 and IL-8 increased after PFI treatment.

Sedentary individuals may experience different myokine responses to pharmacological treatments mimicking exercise.

Body mass index (BMI) is a risk factor for the development of oesophageal adenocarcinoma, colorectal, hepatocellular, gallbladder, and pancreatic cancers.

Practitioners should consider BMI as a significant factor in assessing cancer risk in patients with excess adiposity.

Indices of increased central adiposity, such as waist circumference, are associated with increased risk of oesophageal adenocarcinoma and colorectal cancer.

Practitioners should monitor waist circumference as a potential risk factor for certain gastrointestinal cancers.

MijnEetmeter food diary moderately underestimates intakes of energy and some nutrients and food groups.

Practitioners should be aware that MijnEetmeter may not provide accurate dietary intake assessments.

Correlations between 3-day mean intakes for energy and six key nutrients were above 0.7 except for sodium intake.

High correlations suggest that MijnEetmeter can be a reliable tool for tracking most nutrients.