Browse the evidence

GLP-1 receptor agonists safely cause weight loss and have potential weight-independent anti-inflammatory effects.

Practitioners may consider GLP-1 receptor agonists as a treatment option for weight loss and inflammation in these patient populations.

Significant increases were observed in phase angle (PhA), muscle quality index (MQI), muscular strength, muscle mass, and reactance after 12 weeks of resistance training.

Resistance training can lead to significant improvements in various physical health metrics in older women.

A diet that recapitulated key characteristics of non-industrialized dietary patterns improved gut microbiome interactions and provided cardiometabolic benefits.

Practitioners may consider recommending dietary patterns that mimic non-industrialized diets to improve gut health and cardiometabolic outcomes.

Primary prevention of type 2 diabetes (T2D) should be achievable through the implementation of early and sustainable measures.

Implement early and sustainable prevention measures for at-risk individuals.

Intensive, multicomponent behavioural interventions for overweight and obese adults can lead to weight loss.

Encourage intensive behavioral interventions for weight management in obese adults.

Nutrition education is the cornerstone of a healthy lifestyle.

Incorporate nutrition education into health promotion strategies.

Resistance training for 12 weeks significantly increased phase angle by 7.4% in older women compared to a control group which experienced a decrease of 3.6%.

Incorporating resistance training can enhance cellular health in older women.

Cholesterol reduction combined with aggressive management of modifiable risk factors can help reduce and prevent morbidity and mortality in individuals at increased risk of cardiovascular events.

Practitioners should focus on cholesterol reduction and managing lifestyle factors to improve cardiovascular health.

Therapeutic lifestyle change is the mainstay of management for all patients with dyslipidaemia.

Healthcare providers should prioritize lifestyle modifications in treating dyslipidaemia.

Weight loss and fat mass loss through lifestyle and pharmacologic interventions improve metabolic and inflammatory markers, suggesting a link to decreased breast cancer risk.

Practitioners should encourage weight loss and fat mass reduction as strategies to lower breast cancer risk.

bMVPA performed in the afternoon is associated with a greater reduction in HbA1c compared to inactive individuals, with a reduction of -0.22%.

Practitioners may consider recommending afternoon physical activity to improve glycemic control in patients with type 2 diabetes.

Whey protein supplementation combined with resistance training leads to a 4.8% increase in skeletal muscle mass in older women compared to a 2.3% increase with placebo.

Practitioners should consider whey protein supplementation to enhance muscle mass in older women undergoing resistance training.

Whey protein supplementation combined with resistance training results in an 8.7% increase in total strength compared to a 4.9% increase with placebo.

Whey protein supplementation may significantly enhance strength gains in older women participating in resistance training.

Both whey protein and placebo groups showed significant improvements in muscular quality, with the whey protein group showing a 2.9% increase compared to a 1.5% increase in the placebo group.

Both whey protein and resistance training can improve muscular quality in older women.

Supporting an athlete's need for autonomy by allowing choices concerning training variables can be an effective coaching strategy.

Coaches should incorporate autonomy in training to enhance effectiveness.

Autonomy support has been shown to improve motor learning, performance, and motivation.

Enhancing autonomy can lead to better learning and performance outcomes.

The review discusses the positive effects of providing choices to athletes.

Providing choices can enhance the training experience for athletes.

Therapeutic strategies that promote significant and sustained weight loss (~10% of total body weight) are among the most efficient for treating NASH and T2D.

Weight loss interventions should be prioritized in managing NASH and T2D.

Tirzepatide would avert 45,609 obesity cases per 100,000 individuals over a lifetime.

Tirzepatide is effective in reducing obesity cases, suggesting its potential use in clinical practice.

Semaglutide would avert 32,087 obesity cases per 100,000 individuals over a lifetime.

Semaglutide is effective in reducing obesity cases, suggesting its potential use in clinical practice.

Bariatric surgery is associated with more robust weight loss (15–64.6%) and improvement in obstructive sleep apnea severity and gas exchange.

Bariatric surgery may be a more effective intervention for significant weight loss and improvement in respiratory function in OHS patients.

The guideline panel made a conditional recommendation for a weight loss intervention targeting a sustained weight loss of 25% to 30% of actual body weight.

Clinicians should consider recommending significant weight loss for OHS patients, while being aware of the low-quality evidence supporting this recommendation.

Using an internal focus of attention during resistance training resulted in a 12.4% increase in elbow flexor thickness compared to a 6.9% increase with an external focus.

Practitioners should consider encouraging an internal focus during resistance training to enhance muscle growth.

The findings support the use of a mind-muscle connection to enhance muscle hypertrophy.

Emphasizing the mind-muscle connection may improve training outcomes for hypertrophy.