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RMR was not related to any markers of oxidative stress.

Practitioners may need to reconsider the role of metabolic rate in oxidative stress and aging.

There is no significant effect of exercise order on muscle hypertrophy (ES = 0.03; p = 0.862).

Exercise order may not need to be a primary concern for hypertrophy outcomes.

Daily energy deficit was not significantly associated with change in cognitive test performance.

Practitioners should note that energy deficits from dieting may not impact cognitive performance.

No consistent pattern of verbal memory, visual retention/memory, or attention/concentration deficits emerged during the trial.

Practitioners can conclude that calorie restriction does not lead to cognitive deficits in the areas tested.

The U.S. Department of Agriculture's 1991 withdrawal of its Eating Right Pyramid food guide was influenced by pressure from meat and dairy producers.

Practitioners should be aware of the potential influence of food industry lobbying on dietary guidelines.

There is a conflict of interest in the Department of Agriculture's dual mandates to promote U.S. agricultural products and to advise the public about healthy food choices.

Practitioners should be aware of potential biases in dietary recommendations due to conflicting interests.

More randomized clinical trials are needed to examine the relative utility of different dietary factors in the treatment of obesity.

There is a need for more research to identify effective dietary strategies for obesity treatment.

Genotype variation at the studied loci did not modify the associations between diet and fasting glucose or insulin levels.

Dietary recommendations can be applied broadly without concern for specific genetic variations at the studied loci.

The dietary treatments did not alter weight, body fat, or lipid profile of the subjects.

Athletes can adopt a high-fat diet without concerns about negative impacts on body composition.

Several biomarkers reflecting various pathophysiological pathways linking obesity and cardiometabolic diseases have been identified.

Practitioners should consider these biomarkers in understanding obesity-related health risks.

The evidence for a causal role of many classical obesity biomarkers in disease etiology remains limited.

Caution is advised when using classical biomarkers for disease prediction.

There is increasing interest in novel biomarkers for improved, personalized prevention of obesity-related diseases.

Practitioners should explore novel biomarkers for better prevention strategies.

Significant disproportionality was detected for semaglutide-associated suicidal ideation (ROR, 1.45; 95% CI, 1.18-1.77; IC, 0.53; 95% CI, 0.19-0.78).

Clinicians should be aware of the potential risk of suicidal ideation in patients treated with semaglutide.

A total of 107 cases of suicidal and/or self-injurious ADRs were reported with semaglutide.

Awareness of the number of reported cases can inform risk assessments for semaglutide use.

The pooled effect on adiponectin from fish feeding was not statistically significant (-0.01 μg/mL, 95% CI -0.65; 0.64, P = 0.99).

Fish feeding may not be an effective method for increasing adiponectin levels.

Modifications to a whole room indirect calorimeter allow accurate measurement of energy expenditure in 1-min intervals.

Practitioners can use this modified calorimeter to study acute effects of food, exercise, or drugs on energy expenditure.

Nutrition researchers and professional societies need to recognize the influence of food-industry sponsorship.

Practitioners should be aware of the potential biases introduced by food-industry funding.

Sponsored studies should promote public health.

Practitioners should ensure that research aligns with public health goals.

There was no difference in 24-h energy expenditure (EE) between Caucasian and Pima Indian men (2,422 vs. 2,523 kcal/24 h).

Practitioners should note that ethnic differences may not significantly affect energy expenditure in these populations.

OSM acts on adipocytes to induce the expression and secretion of plasminogen activator inhibitor 1 and IL-6.

Understanding OSM's role could help in developing strategies to modulate inflammation in obesity.

The subsidy policy for fruits and vegetables would not significantly affect obesity and type 2 diabetes.

Subsidizing fruits and vegetables may not be an effective strategy for reducing obesity and diabetes.

ALA was not associated with T2D risk.

Practitioners should note that ALA does not appear to reduce T2D risk, unlike other n-3 fatty acids.

The highest achieved tertiles of EPA and DHA were associated with neither benefit nor harm in patients at high cardiovascular risk.

Practitioners should note that increasing EPA and DHA levels may not provide cardiovascular benefits in high-risk patients.

Skeletal muscle extracellular matrix remodeling may contribute to the development of metabolic dysfunction associated with energy excess and obesity.

Understanding muscle remodeling may help address metabolic issues related to obesity.