Browse the evidence

Semaglutide treatment resulted in significant reductions in body mass index (BMI), waist circumference, and HbA1c.

Practitioners can consider semaglutide as an effective treatment for reducing BMI and improving glycemic control in obese T2DM patients.

Lifestyle modifications can mitigate cancer risk associated with obesity.

Encouraging lifestyle changes can be a key strategy in cancer prevention efforts.

Novel medications such as GLP-1 agonists have demonstrated sustained weight loss in patients with obesity.

Practitioners can consider GLP-1 agonists as a treatment option for obesity.

The FDA authorizes the use of injectable semaglutide for the treatment of obesity.

Practitioners can consider semaglutide as an approved treatment option for obesity in the U.S.

Bariatric surgery is the most effective treatment for patients with Type 2 diabetes mellitus (T2DM) and obesity.

Clinicians should consider bariatric surgery as a primary treatment option for patients with T2DM and obesity.

Metabolic surgery, intensive lifestyle modification, and pharmacologic approaches are viable options for achieving diabetes remission.

Practitioners should consider these options early in the disease course for better outcomes.

A comprehensive approach is the best way to manage weight.

Practitioners should consider a multifaceted approach to obesity treatment.

Comprehensive management of diabetic nephropathy includes lifestyle interventions and medication selection.

Practitioners should implement lifestyle changes alongside medication for effective management.

Dietary adherence, including protein and salt restriction, is relevant in inhibiting progression of chronic kidney disease.

Dietary recommendations should focus on protein and salt restrictions to manage kidney disease progression.

Exercise is one of the most effective strategies to prevent sarcopenia.

Incorporating exercise into daily routines can significantly help in preventing muscle loss in older adults.

A combination of adequate nutrition and regular exercise is recommended to promote muscle health and function.

Practitioners should encourage both dietary and exercise interventions for optimal muscle health in older adults.

Canagliflozin results in weight loss and reduction of blood pressure.

Incorporating canagliflozin may aid in weight management and blood pressure control for diabetic patients.

The management of MASLD in patients with T2D includes dietary and behavioral management, pharmacological treatment, and bariatric procedures.

Practitioners should consider a comprehensive management approach for diabetic patients with MASLD.

Higher protein diets optimize muscle mass during periods of resistance training, facilitating strength increases.

Athletes should consider higher protein intake to enhance muscle mass and strength.

Creatine monohydrate supplementation enhances strength and power.

Incorporating creatine monohydrate can be beneficial for strength and power training.

Peri-exercise caffeine, nitrate-containing supplements, and sodium bicarbonate can enhance aspects of endurance performance.

Athletes may benefit from these supplements to improve endurance performance.

Behavioral treatment for obesity includes components such as self-monitoring, functional analyses, stimulus control, cognitive restructuring, problem-solving, and relapse prevention.

Practitioners should incorporate these components into obesity treatment programs.

Weight loss requires the induction of a negative energy balance.

Weight loss strategies should focus on creating a negative energy balance.

Patient-delivered lifestyle intervention yielded significantly less weight regain than standard-of-care (SOC) at month 18 (0.77 kg vs 2.37 kg; P = .002).

Patient-delivered interventions may be a viable alternative for weight loss maintenance.

Patient-delivered intervention showed parallel improvements in diastolic blood pressure, heart rate, physical activity, and sedentary behavior compared to SOC.

Improving cardiovascular metrics can enhance overall health in weight maintenance programs.

Both intermittent fasting (IF) and ketogenic diet (KD) independently show clinically significant benefits in improving metabolic parameters in metabolic syndrome (MetS) and type 2 diabetes (T2D), including reductions in HbA1c, fasting glucose, body weight, and triglycerides.

Practitioners may consider IF and KD as effective dietary interventions for managing MetS and T2D.

Competitors generally adjusted resistance training (RT) in a variety of ways during peak week, with proximity-to-failure being the most frequently manipulated variable.

Trainers should consider adjusting training variables like proximity-to-failure for competitors during peak week.

During peak week, frequency, volume, and intensity of resistance training decreased while repetition ranges of compound exercises increased.

Competitors should focus on adjusting their training load to reduce stress while increasing repetitions for compound movements.

Each 100 MET-min/wk increase in accelerometry-measured moderate-to-vigorous physical activity (MVPA) from baseline to 4 years is associated with decreased risk of cardiovascular disease (CVD) outcomes.

Encouraging long-term engagement in MVPA can help reduce CVD risk in this population.