26,927 findings
- Energy balanceStrong
Changes in skeletal muscle mass (SMM) are not associated with improvements in walking speed.
Improvements in walking speed may not require increases in muscle mass, focusing instead on strength and quality.
Refutes 2017 - MolecularStrong
Mitochondrial membrane structure, function, and programmed cell death are regulated by the balance between mitochondrial fusion and fission.
Practitioners should consider the role of mitochondrial dynamics in health and disease.
Supports 2008 - Metabolic adaptationStrong
Plasma TMAO and related metabolites were not significantly associated with type 2 diabetes risk.
The findings suggest that TMAO and related metabolites may not be useful biomarkers for predicting type 2 diabetes risk.
Refutes 2021 - Energy balanceStrong
There were an estimated 1.73-2.20 million people with diabetes in Taiwan in 2014-2015.
Health practitioners should be aware of the significant prevalence of diabetes in Taiwan.
Supports 2019 - Energy balanceStrong
Future studies are needed to refine the conceptual model for smartphone technology in weight loss.
Practitioners and researchers should advocate for and participate in studies that explore smartphone technology's role in weight loss.
Supports 2015 - Energy balanceStrong
Conflicts of interest (COIs) from funders can introduce bias in nutritional evidence.
Practitioners should critically evaluate research findings for potential biases due to COIs.
Supports 2017 - CellularStrong
A novel combination of common variants of HRAS1, LASS1, and APOE is associated with human lifespan and healthy aging.
Practitioners may consider the genetic profiles of HRAS1, LASS1, and APOE when assessing longevity and healthy aging.
Supports 2010 - CellularStrong
An HRAS1 haplotype enhances the effect of an APOE haplotype on exceptional survival.
Understanding the genetic interactions may help in developing strategies for promoting longevity.
Supports 2010 - MolecularStrong
Variation in LASS1 is functional and contributes to healthy aging and greater survival in the tenth decade of life.
Practitioners should consider the role of LASS1 in promoting healthy aging.
Supports 2010 - HormonalStrong
Androstenedione supplementation is unlikely to provide male athletes with any anabolic benefit.
Athletes should be cautious about using androstenedione for performance enhancement as it may not yield expected anabolic effects.
Refutes 2000 - Energy balanceStrong
Future randomized controlled trials should be of >12 months’ duration.
Longer studies are needed to fully assess the impact of carbohydrate restriction on glycaemic control.
Qualifies 2018 - HormonalStrong
A 25% caloric restriction diet for 6 months does not change growth hormone (GH), GH secretion, or insulin-like growth factor (IGF)-1 in nonobese men and women.
Caloric restriction may not be effective for altering GH and IGF-1 levels in nonobese individuals.
Refutes 2009 - NeuralStrong
GLP1-RA treatment is not associated with a significant difference in risk of serious psychiatric adverse events compared with placebo (log[RR] = -0.02; P = .87).
GLP1-RAs can be considered safe regarding serious psychiatric events in this population.
Refutes 2025New - Metabolic adaptationStrong
Two weeks of traditional exercise recommendations (TER) did not improve metabolic functioning in sedentary obese men.
Traditional exercise recommendations may not lead to metabolic improvements in sedentary obese individuals.
Refutes 2013 - Metabolic adaptationStrong
No changes in fasting plasma glucose, insulin, non-esterified fatty acids (NEFA), homeostasis model assessment of insulin sensitivity (HOMA-IR), body composition, and VO(2peak) were observed after training.
Short-term exercise does not lead to changes in key metabolic markers in sedentary obese individuals.
Refutes 2013 - CellularStrong
Mean PSA doubling time (PSADT) was similar between LCD (22 months) and control (15 months, P = 0.313) arms.
A low-carbohydrate diet does not adversely affect PSA doubling time in men with recurrent prostate cancer.
Supports 2020 - CellularStrong
Immobilization does not alter mitochondrial H2O2 emission or markers of cellular redox state.
This suggests that oxidative stress may not be a significant factor in muscle atrophy during immobilization.
Supports 2019 - CellularStrong
Pima Indians have lower fasting plasma magnesium concentration than Caucasians (0.79 +/- 0.05 vs. 0.85 +/- 0.06 mmol/L; P < 0.01).
Lower magnesium levels in Pima Indians may have implications for their metabolic health and insulin sensitivity.
Supports 1995 - Energy balanceStrong
There is a lack of data in female animal models or women regarding GLP-1 research.
More research is needed in female populations to understand GLP-1 effects.
Supports 2024 - Energy balanceStrong
Only 6.2% of the total population reported n-3 fatty acid supplement use, which did not alter median daily intake.
Practitioners should note that supplements are not widely used and do not significantly impact overall n-3 fatty acid intake.
Refutes 2017 - Metabolic adaptationStrong
There were no between-group differences in body composition and adaptive thermogenesis.
Practitioners should note that both diets did not significantly affect body composition or thermogenesis.
Refutes 2022 - Energy balanceStrong
The two methods (MF-BIA and DXA) were poor predictors of each other in regards to changes in segmental measurements.
Practitioners should be cautious when interpreting segmental measurements from these methods.
Refutes 2018 - HormonalStrong
There were no reported hospitalizations from severe hypoglycemia or diabetic ketoacidosis in the treated group.
The safety profile suggests that tirzepatide may be a safe option for managing T1D in this population.
Supports 2024 - HormonalStrong
There is a strong correlation between online search trends and prescriptions for semaglutide (Wegovy) with a correlation coefficient of r = 0.97.
Monitoring online search trends can provide insights into public interest in obesity medications.
Supports 2025New